Why is Gene Profiling Important?
Gene profiling provides insights into how cancer develops, grows, and spreads. It aids in identifying genetic markers that help in selecting targeted therapies, predicting response to treatment, and assessing the risk of recurrence.
Benefits of Gene Profiling
- Enables personalized treatment plans.
- Improves accuracy in cancer diagnosis.
- Identifies targeted therapy options.
- Assists in early detection of genetic predisposition.
- Helps in monitoring treatment efficacy.
Types of Gene Profiling
- Whole Genome Sequencing (WGS): Analyzes the entire DNA sequence of cancer cells.
- Whole Exome Sequencing (WES): Focuses on the protein-coding regions of the genome.
- Transcriptome Profiling: Examines RNA expression levels in tumor cells.
- Gene Expression Analysis: Identifies genes that are over or under-expressed.
- Mutation Profiling: Detects specific mutations linked to cancer development.
What to Expect in Gene Profiling?
Patients provide a tissue or blood sample, which is analyzed in a lab to determine the genetic composition of cancer cells. Oncologists review results to devise a targeted treatment strategy.
Evaluation & Interpretation of Results
Genetic findings are assessed based on the presence of mutations, gene expression levels, and their correlation with cancer treatment options. Reports guide the selection of immunotherapies, targeted therapies, and clinical trials.
Procedure & Duration
- Sample Collection: Blood or tumor biopsy is taken.
- DNA/RNA Extraction: Genetic material is isolated.
- Sequencing & Analysis: Advanced bioinformatics tools analyze the genetic information.
- Report Generation: A detailed genetic report is shared with the oncologist.
The process can take from a few days to a few weeks, depending on the complexity.
Who is a Candidate for Gene Profiling?
- Patients diagnosed with cancer seeking targeted therapies.
- Individuals with a family history of hereditary cancer.
- Patients with rare or aggressive cancers.
- Those undergoing treatment who need alternative options.